Barcelona is capital of Catalonia and world-famous for soccer and architecture. You must visit the cathedral Sagrada Familia, designed by Gaudi, that has been under construction since 1883. Camp Nou, where FC Barcelona resides, is an experience of a different kind.
Santiago de Compostela is the capital of Galicia and the end point of the pilgrimage "Camini de Santiago" and the apostel James should be buried here. The journey here is different from other journeys since people like to either walk or bike.
Cadiz is one of the oldest cities in Europe. It's location is quite unique, since it is surrounded almost completely by water (similar to Venice). James Bond used the city to resemble Cuba.
Cordoba has a beautiful old city center with a lot of charm. The main attraction however is La Mesquita, a cathedral that started as a mosque. Cordoba is one of the hottest cities in Europa in Summer.
Granada is a major tourist destination in Andalusia because of the Alhambra. The nearby Sierra Nevada mountains (3000+m altitude) allow for skiing in winter, with a unique view of the Mediterranean.
Jerez is known mainly for two things: 1) the bodegas for the finest Sherries and 2) the Equestrian School for ultimate horse back riding demonstrations. Add to this great weather, some flamenco and lots of orange trees and then you know something about Jerez de la Frontera.
Madrid, capital of Spain and home of the royal family. The city center with great architecture is amazingly small, with nice places to enjoy local food and wines and very walkable.
Málaga is an important tourist destination, known as "the capital of the Costa del Sol". An estimated 6 million tourists visit the city each year, who usually visit the birthplace of Pablo Picasso.