Los Angeles (aka. City of Angels) is the 2nd largest city in the USA and has a lot to offer, including great shopping (a la Pretty Woman), Hollywood, Venice Beach and sports (L.A. Lakers).
New York City has a few nick names, for example "The Big Apple", "The City That Never Sleeps" and "The Financial Capital of the World". We cannot list everything that there is to do in NYC, because it is too much. The basics however are the Statue of Liberty, Times Square, Broadway, Little Italy / China Town and the Empire State Building.
San Francisco is a favourite city for so many: Americans, Tourists and Homeless. The climate is just perfect for almost anything including growing wine (Napa valley) or computer (Silicon Valley). Tourist will enjoy the local cable train, Alcatraz prison and The Golden Gate bridge.
The Grand Canyon is really grand. When standing on the ridge of the canyon and looking 1 mile (1600m) down to the river Colorado that created all this, you do owe the river a lot of respect. It is possible to walk all the way down and back up in a day, what can be recommended.
Las Vegas is the show and gambling capital of the USA and the Western world. The city is featured in many, many movies and TV series. Las Vegas is a desert city with water coming from Lake Mead.
The Las Vegas strip is the best known with casinos, fancy hotels and top-class resorts. You can also find the Eiffel Tower, Little Venice, a Pyramid and Lady Liberty here. Of course you can get married here with Elvis Presley as your witness.
Monument Valley is a desert with few small, steep rock formations in the shape of monuments. The area is a "classic" and a must-do in the Western USA. Of course it is featured in many movies...
Arches National Park (near Moab) is an area with many rock-formations with some in the shape of an arch (curved with hollow space). Quite pictoresques. Arches N.P. is close to the village of Moab, a starting point for different adventures...
Charleston (South Carolina) has a long history that is reflected in the colonial buildings. Long it has been one of the major cities in the USA. Nowadays it is a real pleasant city.